Diabetes and Tuberculosis: When Scylla Joins Charybdis
نویسنده
چکیده
Tuberculosis has been always considered a major health concern especially for low income countries. People with diabetes have shown increased prevalence of undiagnosed tuberculosis when compared to that of the general population.Research also indicates that those affected with infectious diseases are more likely to develop diabetes. There is enough evidence that demonstrates that people with tuberculosis and diabetes suffer the worse sequelae of both diseases. In these modern times, people with TB should not die, especially with the availability of modern pharmacological therapies and supervised regimens. Unfortunately, premature mortality attributable to both of these chronic diseases remains high. While there is a strong genetic predisposition, the recent rise in the incidence of diabetes suggests that genes alone are necessary but not sufficient to account for the mechanisms involved in diabetes disease onset. Therefore, environmental factors likely play a significant role, but the nature of these putative factors and their influence on the pathogenesis of diabetes is not yet known. Viruses, gut bacteria, nutritional deficiencies and chemicals have all been proposed as environmental catalysts for the development of diabetes. Of these, the intestinal flora (microbiome) is emerging as a critical factor in diabetes pathogenesis. Changes in the microbiome may also affect the immune response against infection. Here we explore how two major public health problems converge.
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تاریخ انتشار 2016